ALS (Amyotrophic lateral sclerosis) Cannabinoids and Medical Marijuana

ALS (Amyotrophic lateral sclerosis)

Cannabinol delays symptom onset
Cannabinol delays symptom onset in SOD1 (G93A) tra…[Amyotroph Lateral Scler Other Motor Neuron Disord. 2005] – PubMed Result

Abstract

Therapeutic options for amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, remain limited. Emerging evidence from clinical studies and transgenic mouse models of ALS suggests that cannabinoids, the bioactive ingredients of marijuana (Cannabis sativa) might have some therapeutic benefit in this disease. However, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the predominant cannabinoid in marijuana, induces mind-altering effects and is partially addictive, compromising its clinical usefulness. We therefore tested whether cannabinol (CBN), a non-psychotropic cannabinoid, influences disease progression and survival in the SOD1 (G93A) mouse model of ALS. CBN was delivered via subcutaneously implanted osmotic mini-pumps (5 mg/kg/day) over a period of up to 12 weeks. We found that this treatment significantly delays disease onset by more than two weeks while survival was not affected. Further research is necessary to determine whether non-psychotropic cannabinoids might be useful in ameliorating symptoms in ALS.

PMID: 16183560 [PubMed – indexed for MEDLINE]

Marijuana in the management of amyotrophic lateral sclerosis (may need free registration)
http://www.medscape.com/medline/abstract/11467101

Cannabis use in patients with amyotrophic lateral sclerosis. (may need free registration)                                                                                                                                  http://www.medscape.com/medline/abstract/15055508

CannabisPotential Exciting Researchers in Treatment of ALS, Parkinson’s Disease
http://www.illinoisnorml.org/index2….o_pdf=1&id=104

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s