Medical Cannabis Marijuana and ANTI-BACTERIAL PROPERTIES of Cannabinoids, Cannabidiol, Cannabichromene, Cannabigerol, Δ9-tetrahydrocannabinol, Cannabinol

Medical Cannabis Marijuana and ANTI-BACTERIAL PROPERTIES of Cannabinoids, Cannabidiol, Cannabichromene, Cannabigerol, Δ9-tetrahydrocannabinol, Cannabinol

Antibacterial Cannabinoids from Cannabis sativa
ACS Publications – Cookie absent

Killing bacteria with cannabis
Killing bacteria with cannabis – Ars Technica

Chemicals in Marijuana May Fight MRSA
Marijuana Ingredients May Fight MRSA

Cannabis Compounds Reduce Multi-Drug Resistant Infections
Cannabis Compounds Reduce Multi-Drug Resistant Infections

Biologically Active Cannabinoids from High-Potency Cannabis sativa.
Unbound MEDLINE | Biologically Active Cannabinoids from High-Potency Cannabis sativa. Journal article

Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study

http://pubs.acs.org/doi/abs/10.1021/np8002673

Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Δ⁹-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance. Activity was remarkably tolerant to the nature of the prenyl moiety, to its relative position compared to the n-pentyl moiety (abnormal cannabinoids), and to carboxylation of the resorcinyl moiety (pre-cannabinoids). Conversely, methylation and acetylation of the phenolic hydroxyls, esterification of the carboxylic group of pre-cannabinoids, and introduction of a second prenyl moiety were all detrimental for antibacterial activity. Taken together, these observations suggest that the prenyl moiety of cannabinoids serves mainly as a modulator of lipid affinity for the olivetol core, a per se poorly active antibacterial pharmacophore, while their high potency definitely suggests a specific, but yet elusive, mechanism of activity.