BRAIN INJURIES and the NEUROPROTECTANT Properties and Therapeutic Effects of Medical Cannabis Marijuana Cannabinoids Tetrahydrocannabinol THC and Cannabidiol CBD

Cannabinoids as Antioxidants and Neuroprotectants United States Patent #6630507

 AbstractCannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH.sub.3, and COCH.sub.3. ##STR1##

Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)

BRAIN INJURIES

How hash became a smash in brain trauma research
MAPS: How hash became a smash in brain trauma research

Synthetic Marijuana Helps Trauma Patients
medical marijuana, medical marijuana canada, compassion club, medical cannabis, medical marijuana vancouver – Synthetic Marijuana Helps Trauma Patients

NEUROPROTECTANT

Marijuana Protects Your Brain
art-mjbrain.html

The neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease
(may need free registration)
http://www.medscape.com/medline/abstract/17196181

Neuroprotective and Intraocular Pressure-Lowering Effects of (-)Delta-THC
Unbound MEDLINE | Neuroprotective and Intraocular Pressure-Lowering Effects of (-)Delta-Tetrahydrocannabinol in a Rat Model of Glaucoma. Journal article

Blue Cheese

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol
Unbound MEDLINE | Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. Journal article

Neuroprotection induced by Delta(9)-tetrahydrocannabinol in AF5 cells
Unbound MEDLINE | Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by Delta(9)-tetrahydrocannabinol in AF5 cells. Journal article

Cannabidiol has a cerebroprotective action
Unbound MEDLINE | Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. Journal article

Cannabidiol but not Delta(9)-THC has a neuroprotective effect without the development of tolerance..
Unbound MEDLINE | Repeated treatment with cannabidiol but not Delta(9)-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Journal article

Delta(9)-THC) prevents cerebral infarction
Unbound MEDLINE | Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Journal article

Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
Unbound MEDLINE | Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity. Journal article

Cannabis and Neuroprotection
AAMC: Cannabis and Neuroprotection

Neuroprotection by Delta 9-THC against Ouabain-Induced In Vivo Excitotoxicity
Neuroprotection by {Delta}9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity — van der Stelt et al. 21 (17): 6475 — Journal of Neuroscience

Jack Herer

Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures
Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures — Nagayama et al. 19 (8): 2987 — Journal of Neuroscience

Cannabinoid activation of PPARalpha; a novel neuroprotective mechanism
British Journal of Pharmacology

The use of cannabinoids in MS: is it evidence based?
http://www.ukcia.org/research/UseOfC…denceBased.pdf

Neurons on Cannabinoids: Dead or Alive?
http://www.ukcia.org/research/NeuronsDeadOrAlive.pdf

Cannabinoids and Brain Injury: Therapeutic Inplications
http://www.ukcia.org/research/Cannab…rainInjury.pdf

Cannabidiol and delta 9-THC are neuroprotective antioxidants
http://www.ukcia.org/research/Neurop…tioxidants.pdf

Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
Cannabidiol and (&#x02212Δ9-tetrahydrocannabinol are neuroprotective antioxidants

Endocannabinoids in the retina: From marijuana to neuroprotection.
Unbound MEDLINE | Endocannabinoids in the retina: From marijuana to neuroprotection. Journal article

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
Unbound MEDLINE | Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. Journal article

OG Kush

Cannabidiol: a promising drug for neurodegenerative disorders?
Unbound MEDLINE | Cannabidiol: a promising drug for neurodegenerative disorders? Journal article

BRAIN INJURIES and the NEUROPROTECTANT Properties and Therapeutic Effects of Medical Cannabis Marijuana Cannabinoids Tetrahydrocannabinol THC and Cannabidiol CBD

Cannabis Documentaries Cannabinoid Facts Marijuana Peer Reviewed Research Links

Cannabis TV Documentaries:

PBS FRONTLINE The Pot Republic

Montana PBS Special Clearing the Smoke: The Science of Cannabis

Hemp for Victory

Reefer Madness

Marijuana ( Marihuana ) The Devil’s Weed Cannabis Propaganda film (1936)

Marihuana The Assassin of Youth 1935 Anti-Marijuana Propaganda Film

The BEST Cannabis / Marijuana Propaganda Films / Movies of ALL TIME!

Marijuana: A Chronic History Presented by the History Channel

NGC’s Drugs Inc.: Marijuana

NGC’s Marijuana Nation

PBS’ Botany of Desire

CNBC’s Marijuana Inc.

TEA Party Eat your Heart Out!! The Bundy’s Were Here 1st!!

Links:

Exploring the Endocannabinoid System Cannabinoids and their Therapeutic Potentials

!!SALE for September!! Grow Buddy Thin Layer Chromatography THC, CBD, Cannabis Cannabinoids Test Kit !!SALE for September!!

Peer Reviewed Research

MMJ Clinics / Doctors Recommendations

MMJ Dispensaries/Caregivers: Find Them Here

MMJ Strains / Varieties: Find Them Here Potency Tested

Ed Rosenthal Runs For President in 2012? Stephen’s Colbert SuperPac Funding?

Fastest way to determine cannabis seedling sex!

Grow Buddy Thin Layer Chromatography THC, CBD test kit

Grow Buddy Instructional Video

Grow Buddy Replacement T.L.C. Supplies

Plant DNA Collection Kit

Montana Biotech Products and Services

Cannabinoid Facts

Specialist Want Regulations / Oversight of Medical Marijuana Analysis Labs, Montana Biotech Embraces Open Dialog

Cannalytics™ Cannabinoid Fingerprinting Test by Alpha Nova vs Grow Buddy™ at Home THC, CBD, CBN Test Kit by Montana Biotech Comparing Two Competing Thin Layer Chromatography T.L.C Methods

QUALTITATIVE vs. QAUNTITATIVE Analysis of Cannabis THC, CBD, CBN Cannabinoid Levels

Ed Rosenthal and the Party-Party’s Platform for America 2012!

A Little Ed History and Education! Wiki Style!

Montana Biotech Laboratory Offers a Cannabis Marijuana Cannabinoid Potency Test Kit Analyze for THC CBD THCV at Home with Grow Buddy Thin Layer Chromatography TLC Qualitative Analysis System Get Results without a Gas Chromatography GC or High Pressure Liquid Chromatography HPLC Machine

Peer Reviewed Research:

ADD /ADHD, Medical Marijuana and its potential Treatment.

Addiction Risk-Physical of using Medical Marijuana.

Alcoholism and Medical Marijuana.

ALS, Lou Gehrig’s Disease Medical Cannabis Therapy

Cannabis Marijuana Use and AMOTIVATIONAL SYNDROME

Alzheimer’s Disease Progression Prevention Cannabinoids

Medical Cannabis Marijuana and ANTI-INFLAMMATORY PROPERTIES of Cannabinoids

ANTI-BACTERIAL PROPERTIES of Cannabinoids, Cannabidiol,  Cannabichromene, Cannabigerol, Δ9-tetrahydrocannabinol, Cannabinol

Medical Cannabis Marijuana and ANTI-INFLAMMATORY PROPERTIES of Cannabinoids

Cannabinoids, Cannabidiol CBD,  Cannabichromene CBC, Cannabigerol CBG, Δ9-tetrahydrocannabinol THC, Cannabinol CBN and Cannabis Marijuana Antioxidant Properties

Cannabis Marijuana and ANXIOLYTIC, Also Known as Antipanic or Antianxiety Agents, EFFECTS of CBD Cannabidiol for Treatment of Anxiety

APPETITE STIMULANT Medical Marijuana Cannabis and It’s Effects on Hunger the Munchies

ARTHRITIS Cannabis Marijuana and the Effects of Cannabinoids for Treatment

ASTHMA Medical Cannabis /  Marijuana and Cannabinoids Therapeutic Effects on Bronchodilation

Cannabinoinds Therapeutic Effects on ATHEROSCLEROSIS, Medical Cannabis Marijuana Research Cannabidiol THC

Autism the Use of Medical Cannabis Marijuana Derived Cannabinoids for Treatment of Disorder

Bipolar Disorder Mood Stabilizing Effects of Medical Cannabis Derived Cannabinoids THC, CBD Treatments and Therapeutic Potential of Marijuana

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